• learning deficits in rats overexpressing the dopamine

    Learning deficits in rats overexpressing the dopamine

    2018-09-21· The present study investigated whether an imbalance in dopamine homeostasis as evident in the dopamine overexpressing rat model (DAT-tg), results in learning and memory deficits associated with changes in adult hippocampal neurogenesis. Adult DAT-tg and control rats were subjected to the Morris water maze, the radial arm maze and a

  • rats overexpressing the dopamine transporter display

    Rats overexpressing the dopamine transporter display

    2016-12-15· Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders Skip to main content Thank you for

  • (pdf) rats overexpressing the dopamine transporter

    (PDF) Rats overexpressing the dopamine transporter

    PDF The dopamine transporter (DAT) plays a pivotal role in maintaining optimal dopamine signaling. DAT-overactivity has been linked to various Find, read and cite all the research you need

  • learning deficits in rats overexpressing the dopamine

    Learning deficits in rats overexpressing the dopamine

    2018-09-21· Experiments were conducted on male hemizygous dopamine transporter overexpressing rats (DAT-tg) and their respective control littermates (wildtypes, wt) as outlined in Fig. 1.

  • rats overexpressing the dopamine transporter display

    Rats overexpressing the dopamine transporter display

    Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders Ravit Hadar1, Henriette Edemann-Callesen1,2, Claudia

  • rats overexpressing the dopamine transporter display

    Rats overexpressing the dopamine transporter display

    Item Type: Article: Title: Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders: Creators Name:

  • rats overexpressing the dopamine transporter display

    Rats overexpressing the dopamine transporter display

    The dopamine transporter (DAT) plays a pivotal role in maintaining optimal dopamine signaling. DAT-overactivity has been linked to various neuropsychiatric disorders yet so far the direct pathological consequences of it has not been fully assessed. We here generated a transgenic rat model that via pronuclear microinjection overexpresses the DAT gene. Our results demonstrate that DAT

  • rats overexpressing the dopamine transporter display

    Rats overexpressing the dopamine transporter display

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  • increased amphetamine-induced hyperactivity and reward

    Increased amphetamine-induced hyperactivity and reward

    2008-03-18· Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter. These animals display increased behavioral responses to the stimulant and rewarding effects of amphetamine, indicating that DAT levels are critical for these properties of amphetamine. Furthermore, these data suggest that hypofunction of the DA system through increased

  • dissociation of wanting and liking in the sucrose

    Dissociation of wanting and liking in the sucrose

    ‘Wanting’ was not entirely abolished in DAT-tg rats, as evidenced by the fact that their consumption of sucrose solution rose beyond their baseline consumption rate for water. This was to be expected, as DAT-tg rats display only a moderate reduction in DA levels

  • increased amphetamine-induced hyperactivity

    Increased amphetamine-induced hyperactivity

    2008-03-18· Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter. These animals display increased behavioral responses to the stimulant and rewarding effects of amphetamine, indicating that DAT levels are critical for these properties of amphetamine. Furthermore, these data suggest that hypofunction of the DA system through increased

  • increased amphetamine-induced hyperactivity and reward

    Increased amphetamine-induced hyperactivity and reward

    and reward in mice overexpressing the dopamine transporter The dopamine transporter (DAT) plays a key role in the regulation of dopaminergic signaling wherein it controls both the spatial and temporal actions of dopamine. Here we evaluated the behavioral and neurochemical consequences of increased DAT function by generating DAT transgenic mice (DAT-tg) that overexpress the transporter

  • temporal expression of mutant lrrk2 in adult rats

    Temporal Expression of Mutant LRRK2 in Adult Rats

    No direct interaction of mutant LRRK2 with dopamine transporter. Microdialysis revealed that dopamine reuptake was impaired in aged rats expressing mutant LRRK2 temporally in adulthood (Fig. 3). To further assess the potential interaction of mutant LRRK2 with DAT, we used the neuroblastoma cells SH-SY5Y as an in vitro model of dopaminergic

  • modulation of dopamine transporter activity by nicotinic

    Modulation of Dopamine Transporter Activity by Nicotinic

    The rat dopamine transporter (rDAT), plentiful in the presynaptic plasma membrane of dopaminergic termi-nals, contains 12 transmembrane domains and belongs to the Na1/Cl2-dependent transporter family (Kilty et al., 1991; Amara and Arriza, 1993; Giros and Caron, 1993). The principal function of the dopamine transporter (DAT) is to control the synaptic levels of dopamine by reuptake of dopamine

  • anti-dopamine transporter antibody (ab111468) abcam

    Anti-Dopamine Transporter antibody (ab111468) Abcam

    If you wanted to do in vivo testing, please note that Anti-Dopamine Transporter antibody (ab111468) and Anti-Dopamine Transporter antibody (ab111468) have 0.02% sodium azide in them as a preservative and that this would have to be removed before in vivo testing in rats as it could be harmful to them. Read More

  • dopamine transporter

    Dopamine transporter

    The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol. In the cytosol, other transporters sequester the dopamine into vesicles for storage and later release.

  • publications charité

    Publications Charité

    Dissociation of wanting and liking in the sucrose preference test in dopamine transporter overexpressing rats.

  • the role of dopamine transporter in selective toxicity

    The role of dopamine transporter in selective toxicity

    The dopamine transporter has been shown to be the most relevant target site for the specificity of 1-methyl-4-phenylpyridinium ion (MPP +), a neurotoxin for dopaminergic neurons.In contrast, the mechanisms underlying the selective toxicity of manganese and rotenone, potentially toxic agents implicated in dopaminergic neuronal cell death, remain unknown.

  • neurotransplantation of stem cells genetically modified

    Neurotransplantation of stem cells genetically modified

    Neurotransplantation of stem cells genetically modified to express human dopamine transporter reduces alcohol consumption By Tom N Grammatopoulos, Susan M Jones, Masami Yoshimura, Brian R Hoover, Mita Das, Evan Y Snyder, Gaynor A Larson, Nancy

  • quantitative proteomics of synaptosomal fractions in a rat

    Quantitative Proteomics of Synaptosomal Fractions in a Rat

    Disrupted-in-schizophrenia 1 (DISC1) is a key protein involved in behavioral processes and various mental disorders, including schizophrenia and major depression. A transgenic rat overexpressing non-mutant human DISC1, modeling aberrant proteostasis of the DISC1 protein, displays behavioral, biochemical and anatomical deficits consistent with aspects of mental disorders, including changes in

  • the role of dopamine transporter in selective toxicity

    The role of dopamine transporter in selective toxicity

    The dopamine transporter has been shown to be the most relevant target site for the specificity of 1-methyl-4-phenylpyridinium ion (MPP +), a neurotoxin for dopaminergic neurons.In contrast, the mechanisms underlying the selective toxicity of manganese and rotenone, potentially toxic agents implicated in dopaminergic neuronal cell death, remain unknown.

  • autdb autism database search

    AutDB Autism Database Search

    Relevance to Autism . Functional characterization of a de novo missense variant in the SLC6A3 gene originally identified in a simplex ASD case as part of a whole-exome sequencing study in 175 ASD parent-child trios (originally described by Neale et al. in a 2012 Nature report) showed that this variant (T356M) resulted in anomalous dopamine transporter function and hyperactivity when expressed

  • age-dependent dopamine transporter dysfunction

    Age-dependent dopamine transporter dysfunction

    2017-03-14· In vivo striatal dopamine release was insensitive to the LRRK2 inhibitor Nov-LRRK2-11, and was elevated by the membrane dopamine transporter blocker GBR-12783. However, G2019S knock-in mice showed a blunted neurochemical and motor activation response to GBR-12783 compared to wild-type controls. Western blot and dopamine uptake analysis revealed

  • lewis and fischer rats: a comparison of dopamine

    Lewis and Fischer rats: a comparison of dopamine

    Lewis and Fischer rats: a comparison of dopamine transporter and receptors levels Gonzalo Flores, Graham K. Wood, David Barbeau, Rémi Quirion, Lalit K. Srivastava . Abstract Previous reports have shown that fue inbred strains of rat, Lewis (LEW) and Fischer

  • learning deficits in rats overexpressing the dopamine

    Learning deficits in rats overexpressing the dopamine

    X-MOL提供的期刊论文更新,Scientific Reports——Learning deficits in rats overexpressing the dopamine transporter.,Nadine Bernhardt, Maike Kristin Lieser, Elizabeth-Barroeta Hlusicka, Bettina Habelt, Franziska Wieske, Henriette Edemann-Callesen, Alexander Garthe, Christine Winter

  • core

    CORE

    The tgDISC1 rat displayed mainly perinuclear DISC1 aggregates in neurons. Furthermore, the tgDISC1 rat showed a robust signature of behavioral phenotypes that includes amphetamine supersensitivity, hyperexploratory behavior and rotarod deficits, all pointing to changes in dopamine (DA) neurotransmission. To understand the etiology of the

  • age-dependent dopamine transporter dysfunction

    Age-dependent dopamine transporter dysfunction

    Nov-LRRK2-11, and was elevated by the membrane dopamine transporter blocker GBR-12783. However, G2019S knock-in mice showed a blunted neurochemical and motor activation response to GBR-12783 compared to wild-type controls. Western blot and dopamine uptake analysis revealed an increase in dopamine transporter levels and

  • frontiers behavioral phenotyping of dopamine

    Frontiers Behavioral Phenotyping of Dopamine

    Such diseases typically feature poor decision making and lack of control on executive functions and have been studied through the years using many animal models. Dopamine transporter (DAT) knockout (KO) and heterozygous (HET) mice, in particular, have been widely used to study ADHD. Recently, a strain of DAT KO rats has been developed (1). Here

  • increased amphetamine-induced hyperactivity and reward

    Increased amphetamine-induced hyperactivity and reward

    Sigma-Aldrich offers abstracts and full-text articles by [Ali Salahpour, Amy J Ramsey, Ivan O Medvedev, Brian Kile, Tatyana D Sotnikova, Ericka Holmstrand, Valentina Ghisi, Peter J Nicholls, Ling Wong, Karen Murphy, Susan R Sesack, R Mark Wightman, Raul R Gainetdinov, Marc G Caron].

  • dopamine transporter

    Dopamine transporter

    The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol. In the cytosol, other transporters sequester the dopamine into vesicles for storage and later release.

  • research paper temporal expression of mutant lrrk2

    Research Paper Temporal Expression of Mutant LRRK2

    LRRK2G2019S in adult rats impaired dopamine reuptake by dopamine transporter (DAT) and thus enhanced locomotor activity, the phenotypes that were not observed in trans-genic rats constitutively expressing the gene throughout life time. Reduced DAT binding activity is an early sign of dopaminergic dysfunction in asymptomatic subjects carrying

  • dopamine and amphetamine rapidly increase dopamine

    Dopamine and Amphetamine Rapidly Increase Dopamine

    2009-03-11· Rat dopamine transporter with a fluorescent tag [green fluorescent protein (GFP)-DAT] was created by fusing the coding region of enhanced GFP (EGFP) from pEGFP-C2 vector (Clontech) to the N terminus of the rat DAT cDNA between EcoRI and KpnI sites in the multicloning site of the vector.

  • novel translational rat models of dopamine transporter

    Novel translational rat models of dopamine transporter

    Novel translational rat models of dopamine transporter deficiency Damiana Leo 1, Ilya Sukhanov 2, Raul R Gainetdinov PhD 3 1 Department of Neurosciences, University of Mons, Mons, Belgium 2 Institute of Pharmacology, Pavlov Medical University, St. Petersburg, Russia 3 Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia

  • increased amphetamine-induced hyperactivity and reward

    Increased amphetamine-induced hyperactivity and reward

    The dopamine transporter (DAT) plays a key role in the regulation of dopaminergic signaling wherein it controls both the spatial and temporal actions of dopamine. Here we evaluated the behavioral and neurochemical consequences of increased DAT function by generating DAT transgenic mice (DAT-tg) that overexpress the transporter. These mice were

  • dat1 dopamine transporter homo sapiens (human)

    DAT1 Dopamine transporter Homo sapiens (Human)

    UniProtKB. x; UniProtKB. Protein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects.

  • differential influence of dopamine transport rate on the

    Differential Influence of Dopamine Transport Rate on the

    Dopamine transporter (DAT) levels vary across brain regions and individuals, and are altered by drug history and disease states; however, the impact of altered DAT expression on psychostimulant effects in brain has not been systematically explored. Using fast scan cyclic voltammetry, we measured the effects of elevated DAT levels on presynaptic dopamine parameters as well as the uptake

  • core

    CORE

    eds (2005) The behaviour of the laboratory rat: a handbook with tests. (2003). Generation and characterization of chimeric recombinant AAV vectors. (2008). Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter. (2006). Lewy bodies. (2004). Lewy bodyrelated alpha-synucleinopathy in aging. (2004

  • beyond camp: the regulation of akt and gsk3

    Beyond cAMP: The Regulation of Akt and GSK3

    (2009). Reduced D2-mediated activity and transsynaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. (2011). Regulation of Akt and GSK3 by dopamine (2007). Regulation of Akt signaling by D2 and D3 dopamine r e c e p t o r si nv i v o .J.

  • forschungsbereich: neurobiologie psychiatrischer

    Forschungsbereich: Neurobiologie Psychiatrischer

    Meyerolbersleben L, Winter C, Bernhardt N. Dissociation of wanting and liking in the sucrose preference test in dopamine transporter overexpressing rats. accepted 16-Sep-2019 Behav Brain Res.

  • striatal dopamine transmission is subtly modified

    Striatal Dopamine Transmission Is Subtly Modified

    Unaltered Striatal Dopamine Release Levels in Young Parkin Knockout, Pink1 Knockout, DJ-1 Knockout and LRRK2 R1441G Transgenic Mice. Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System

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