• pamam dendrimers dendrimers sigma-aldrich

    PAMAM Dendrimers Dendrimers Sigma-Aldrich

    Polyamidoamine (PAMAM) dendrimers are the most common class of dendrimers suitable for many materials science and biotechnology applications. PAMAM dendrimers consist of alkyl-diamine core and tertiary amine branches. They are available in generations (G) 0 to 10 with 5 different core types and 10 functional surface groups. Most PAMAM dendrimers are supplied as solutions in methanol for

  • pamam dendrimers sigma-aldrich

    PAMAM Dendrimers Sigma-Aldrich

    Search results for PAMAM Dendrimers at Sigma-Aldrich. Compare Products: Select up to 4 products. *Please select more than one item to compare

  • amino surface groups pamam dendrimers sigma-aldrich

    Amino Surface Groups PAMAM Dendrimers Sigma-Aldrich

    31 行· The amino surface consists of polar, highly reactive primary amine surface groups. The

  • dendrimers nanomaterials sigma-aldrich

    Dendrimers Nanomaterials Sigma-Aldrich

    Dendrimers are highly branched, star-shaped macromolecules with nanometer-scale dimensions. Dendrimers are defined by three components: a central core, an interior dendritic structure (the branches), and an exterior surface with functional surface groups. They are synthesized by step-wise chemical methods to give distinct generations (G0, G1, G2, etc.) of molecules with narrow

  • dendrimers sigma-aldrich

    dendrimers Sigma-Aldrich

    PAMAM-succinamic acid dendrimer, 1,12-diaminododecane core, generation 6 solution. 1 Product Result

  • sodium carboxylate surface groups pamam dendrimers

    Sodium Carboxylate Surface Groups PAMAM Dendrimers

    17 行· Sodium carboxylate is an anionic surface group. PAMAM dednrimers with sodium carboxylate

  • succinamic acid surface groups pamam dendrimers

    Succinamic Acid Surface Groups PAMAM Dendrimers

    Succinamic acid is an acidic surface group. PAMAM dednrimers with succinamic acid surfaces offer anionic surface groups, typical carboxylic acid reactivity and the potential to make carboxylate salts for a variety of reaction capabilities. Note that PAMAM dednrimers with succinamic acid surfaces are insoluble in methanol and are supplied as solutions in water.

  • pamam dendrimers

    PAMAM Dendrimers

    The term "dendrimer" was derived from its tree-like branching structure. The tables below show the calculated properties* of primary amine surface PAMAM dendrimers by generation, followed by common alternative surfaces. For mixed surfaces or other customized dendrimers, please inquire.

  • dendrimers an overview sciencedirect topics

    Dendrimers an overview ScienceDirect Topics

    PAMAM dendrimers have several applications in pharmaceutical and biomedical fields. It has also been used for gene delivery and delivery of diagnostic agents. PAMAM dendrimers are nonimmunogenic, are water soluble, and possess terminal functional groups for binding various targeting or guest molecules. PAMAM dendrimers generally display

  • cationic pamam dendrimers disrupt key platelet functions

    Cationic PAMAM dendrimers disrupt key platelet functions

    2012-06-04· Data shown for PAMAM dendrimer-platelet reactivity compliment recently published related data suggesting that cationic PAMAM dendrimers cause platelet activation and aggregation 28 by further elucidating mechanisms by which higher generation (G7), more densely cationic PAMAM dendrimers affect platelet morphology and functions in blood.

  • cationic pamam dendrimers disrupt key platelet functions

    Cationic PAMAM dendrimers disrupt key platelet functions

    2012-06-04· Data shown for PAMAM dendrimer-platelet reactivity compliment recently published related data suggesting that cationic PAMAM dendrimers cause platelet activation and aggregation 28 by further elucidating mechanisms by which higher generation (G7), more densely cationic PAMAM dendrimers affect platelet morphology and functions in blood.

  • low-level detection of poly(amidoamine) pamam

    Low-Level Detection of Poly(amidoamine) PAMAM

    The capture assay platform has shown the potential for low-level detection and quantification of G4 biotinylated PAMAM dendrimers. Further improvements in the performance of this immunosorbent assay approach such as the reduction of incubation times may be possible by utilizing a rotating capture substrate to increase the flux of analyte to the capture surface [].

  • new advances in general biomedical applications

    New Advances in General Biomedical Applications

    2018-11-02· 3. Structure and Synthesis. PAMAM was the first dendrimer that was synthesized and commercialized, and it is the most well-studied and well-characterized class of dendrimers [].There are many general approaches for dendrimer synthesis, with convergent [] and divergent methods [] being the most commonly used methods.In the last few years, some new methodologies have been developed,

  • polyamidoamine (pamam) dendrimers synthesis

    Polyamidoamine (PAMAM) dendrimers synthesis

    PAMAM dendrimers were characterized by the techniques like UV-Vis, SEM, FTIR and particle size analysis UV-Vis spectroscopy provides the evidence of synthesis as well as the conjugation (surface modification) on dendrimers due to characteristic shift in value of lambda max.

  • (pdf) pamam dendrimer for mitigating humic foulant

    (PDF) PAMAM dendrimer for mitigating humic foulant

    Poly(amidoamine) (PAMAM) dendrimers have been established as efficient ligands for the removal of humic acid (HA) foulant, based upon electrostatic and hydrophobic interactions, as well as

  • poly(amidoamine)

    Poly(amidoamine)

    Poly(amidoamine), or PAMAM, is a class of dendrimer which is made of repetitively branched subunits of amide and amine functionality.PAMAM dendrimers, sometimes referred to by the trade name Starburst, have been extensively studied since their synthesis in 1985, and represent the most well-characterized dendrimer family as well as the first to be commercialized.

  • nitric oxide-releasing amphiphilic poly(amidoamine)

    Nitric Oxide-Releasing Amphiphilic Poly(amidoamine)

    2013-10-14· Synthesis of Secondary Amine- and N-Diazeniumdiolate-Functionalized PAMAM Dendrimers. Secondary amine-functionalized PAMAM dendrimers (generation 1 or G1 and generation 3 or G3) were synthesized as described previously. 32 Briefly, primary amine-functionalized G1-PAMAM dendrimer (100 mg) was dissolved in methanol (2 mL). One molar equivalent of PO, ED, or a mixture

  • pamam dendrimers as quantized building blocks

    PAMAM Dendrimers as Quantized Building Blocks

    2013-12-21· PAMAM dendrimers have been extensively studied as nanoscale biomedical devices due to their low polydispersity, multiple sites for chemical modification, flexibility, water solubility at high generations, and biocompatibility. 15, 41, 42 Recent work has employed rp-HPLC to remove both generational and oligomer (primarily dimer and trimer

  • pamam dendrimers as efficient drug and gene delivery

    PAMAM dendrimers as efficient drug and gene delivery

    The size and shape of G3, G4 and G5 PAMAM dendrimers are similar to insulin, cytochrome C and hemoglobin, respectively justifying the description of their properties as “artificial proteins”. PAMAM dendrimers have internal cavities and peripheral functional groups that can be modified to encapsulate drugs or other cargos. Controlling

  • pricing & ordering dendritech

    Pricing & Ordering Dendritech

    The ability to produce large scaleup quantities of dendrimers from on-site manufacturing is a unique Dendritech strength and we welcome inquiries on pricing and products. Pricing & Ordering. PAMAM dendrimers are available directly from Dendritech, Inc. with some minimum order quantities required. Smaller research quantities of the following

  • pamam dendrimers and graphene: materials

    PAMAM Dendrimers and Graphene: Materials

    We present results from experiments and atomistic molecular dynamics simulations on the remediation of naphthalene by polyamidoamine (PAMAM) dendrimers and graphene oxide (GrO). Specifically, we investigate 3rd–6th generation (G3-G6) PAMAM dendrimers and GrO with different levels of oxidation. The work is motivated by the potential applications of these emerging nanomaterials in removing

  • pamam dendrimers with an oxyethylene unit-enriched

    PAMAM Dendrimers with an Oxyethylene Unit-Enriched

    In addition, the in vitro cytotoxicity of temperature-sensitive dendrimers at incubation temperatures below and above LCST was much lower than that of their parent PAMAM dendrimers. Results indicate that the dendrimers with oxyethylene unit-enriched surface might be promising to construct intelligent drug delivery systems.

  • dendrimer

    Dendrimer

    Dendrimers also are used in the synthesis of monodisperse metallic nanoparticles. Poly(amidoamide), or PAMAM, dendrimers are utilized for their tertiary amine groups at the branching points within the dendrimer. Metal ions are introduced to an aqueous dendrimer solution and the metal ions form a complex with the lone pair of electrons present

  • biodistribution of fluorescently labeled pamam

    Biodistribution of Fluorescently Labeled PAMAM

    2013-12-02· Previous studies of PAMAM dendrimers in large animals indicated an opportunity for preoperative lymphatic mapping for surgical planning and the study of lymphangiogenesis in humans. 41 In this study, a rabbit model of neonatal/pediatric brain injury is used to evaluate dendrimer biodistribution. Based on these results, the distribution and

  • differences in toxicity of anionic and cationic pamam

    Differences in toxicity of anionic and cationic PAMAM

    2016-08-15· The chorion proved a significant influencing factor regarding the size and thus, the generation of the dendrimers. Anionic PAMAM dendrimers showed little to no fish embryo and cell toxicity at the concentrations tested, but adverse effects on aquatic organisms at higher concentrations > 50 μM cannot be ruled out.

  • pamam dendrimers: destined for success or doomed to

    PAMAM Dendrimers: Destined for Success or Doomed to

    2014-10-31· PAMAM dendrimers were, for the first time, synthesized in 1984 by Donald Tomalia, a pioneer chemist in the field of dendrimers. 8 Initially, only very few laboratories were interested in studying these polymers. Later, however, researchers have realized that dendrimers have some special properties to offer. During recent years, dendrimers have attracted considerable interest from both

  • pamam dendrimers for sirna delivery: computational

    PAMAM Dendrimers for siRNA Delivery: Computational

    PAMAM dendrimers are chosen as a model nanomaterial due to their widely studied cytotoxic and genotoxic properties and commercial availability. Point spectra were acquired from cytoplasm to

  • improved large scale synthesis and characterization

    Improved Large Scale Synthesis and Characterization

    Draft 1 1 Improved Large Scale Synthesis and Characterization of Small and 2 Medium Generation PAMAM-dendrimers 3 4 Mario Ficker, Valentina Paolucci, Jørn B. Christensen* 5 Department of Chemistry, University of Copenhagen, Thorvaldsensvej 40, Frederiksberg, DK-1871

  • (pdf) structure of pamam dendrimers: generations 1

    (PDF) Structure of PAMAM Dendrimers: Generations 1

    Structure of PAMAM Dendrimers: Generations 1 through 11 Prabal K. Maiti, † Tahir C ¸ ag ˇ ın, Guofeng Wang, and William A. Goddard, III* Materials and Process Simulation Center, Beckman

  • poly(amidoamine) (pamam) dendrimers:

    Poly(amidoamine) (PAMAM) dendrimers:

    Poly(amidoamine) (PAMAM) dendrimers are the first complete dendrimer family to be synthesized, characterized and commercialized. Based on this extensive activity, they are recognized as a unique new class of synthetic nanostructures. Dendrimers allow the precise control of size, shape and placement of functional groups that is desirable for

  • pamam dendrimer cell membrane interactions

    PAMAM dendrimer cell membrane interactions

    PAMAM dendrimers have been conjectured for a wide range of biomedical applications due to their tuneable physicochemical properties. However, their application has been hindered by uncertainties in their cytotoxicity, which is influenced by dendrimer generation (i.e. size and surface group density), surface chemistry, and dosage, as well as cell specificity.

  • doxorubicin-conjugated pamam dendrimers for ph

    Doxorubicin-Conjugated PAMAM Dendrimers for pH

    2018-09-19· Moreover, dendrimers are considered as biocompatible and nonimmunogenic, and the size of dendrimers is small enough (e.g., G5 PAMAM dendrimers have a diameter of 5.4 nm) to allow them to be cleared from the blood through the kidney, solving the requirement of biodegradability [30,35].

  • folate and folate−peg−pamam dendrimers: synthesis

    Folate and Folate−PEG−PAMAM Dendrimers: Synthesis

    Ligand-mediated targeting of drugs especially in anticancer drug delivery is an effective approach. Dendrimers, due to unique surface topologies, can be a choice in this context. In the present study, PAMAM (polyamidoamine) dendrimers up to fourth generation were synthesized and characterized through infrared (IR), nuclear magnetic resonance (NMR), electrospray ionization (ESI) mass

  • pamam dendrimers as efficient drug and gene delivery

    PAMAM dendrimers as efficient drug and gene delivery

    The size and shape of G3, G4 and G5 PAMAM dendrimers are similar to insulin, cytochrome C and hemoglobin, respectively justifying the description of their properties as “artificial proteins”. PAMAM dendrimers have internal cavities and peripheral functional groups that can be modified to encapsulate drugs or other cargos. Controlling

  • structure of pamam dendrimers: generations 1 through

    Structure of PAMAM Dendrimers: Generations 1 through

    2004-07-13· PAMAM dendrimers on controlled pore glass: The effect of tethered dendrimer size and tethered affinity groups NTA and terpy on metal ion and indicator dye uptake. Inorganica Chimica Acta 2014, 409, 127-136. DOI: 10.1016/j.ica.2013.08.006.

  • laboratory synthesis of poly(amidoamine)(pamam)

    Laboratory Synthesis of Poly(amidoamine)(PAMAM)

    PAMAM dendrimers were prepared by the divergent method starting from ethylene diamine as can be seen in Scheme 1. Briefly, a solution of etheylenamine (EA) in methanol was added to methyl acrylate

  • poly(amidoamine) dendrimers: covalent

    Poly(amidoamine) dendrimers: covalent

    PAMAM dendrimers can be readily prepared using the iterative reaction sequence developed by Tomalia and are easily conjugated with various functionalities. Importantly, some PAMAM dendrimers are commercially available at an affordable price. Therefore, the study of PAMAM dendrimers has flourished, and they have been widely implemented in

  • (pdf) intrinsic fluorescence of pamam

    (PDF) Intrinsic Fluorescence of PAMAM

    Intrinsic, non-traditional fluorescence of polyamidoamine (PAMAM) dendrimers that do not possess classical fluorophores has been attracting considerable interest for the last decade.

  • intratumor performance and therapeutic efficacy

    Intratumor Performance and Therapeutic Efficacy

    In recent years, small nanoparticles (NPs) with a diameter of less than 10 nm have aroused considerable interest in biomedical applications. However, their intratumor performance, as well as the antitumor efficacy, has not been well understood due to their size-dependent pharmacokinetics, which presents a formidable challenge for delivering a comparable amount of different small NPs to tumor

  • design, synthesis, and characterization of fully

    Design, Synthesis, and Characterization of Fully

    Dendrimers are interesting candidates for various applications because of the high level of control over their architecture, the presence of internal cavities, and the possibility for multivalent interactions. More specifically, zwitterionic dendrimers modified with an equal number of oppositely charged groups have found use in in vivo biomedical applications. However, the design and control

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