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    Tyrphostin analogs are GPR35 agonists Deng 2011

    2011-05-17· 1 Introduction. GPR35 was first identified to be a class A orphan G protein‐coupled receptor (GPCR) that contains 309 amino acids [].GPR35b, a splicing variant that contains an N‐terminal extension of 31 amino acids, was later discovered in gastric cancer cells in 2004, and shown to be capable of transforming NIH‐3T3 cells [].GPR35 has been found to be expressed in various tissues

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    Discovery of 2-(4-Methylfuran-2(5H)-ylidene)malononitrile

    2011-09-27· Pamoic acid and potent antagonists such as CID2745687 present novel opportunities for expanding the chem. space of GPR35, elucidating GPR35 pharmacol., and stimulating GPR35-assocd. drug development. The authors' results indicate that the unexpected biol. functions of pamoic acid may yield potential new uses for a common drug constituent.

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